Related Products of 17557-76-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 17557-76-5, Name is 4,4′-Diamino-[1,1′-biphenyl]-2,2′-dicarboxylic acid, SMILES is O=C(C1=CC(N)=CC=C1C2=CC=C(N)C=C2C(O)=O)O, belongs to isoquinoline compound. In a article, author is Atobe, Masakazu, introduce new discover of the category.
Discovery of 4,6-and 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C zeta Inhibitors with Fragment-Merging Strategy
Two chemical series of novel protein kinase C zeta (PKC zeta) inhibitors, 4,6-disubstituted and 5,7-disubstituted isoquinolines, were rapidly identified using our fragment merging strategy. This methodology involves biochemical screening of a high concentration of a monosubstituted isoquinoline fragment library, then merging hit isoquinoline fragments into a single compound. Our strategy can be applied to the discovery of other challenging kinase inhibitors without protein-ligand structural information. Furthermore, our optimization effort identified the highly potent and orally available 5,7-isoquinoline 37 from the second chemical series. Compound 37 showed good efficacy in a mouse collagen-induced arthritis model. The in vivo studies suggest that PKC zeta inhibition is a novel target for rheumatoid arthritis (RA) and that 5,7-disubstituted isoquinoline 37 has the potential to elucidate the biological consequences of PKC zeta inhibition, specifically in terms of therapeutic intervention for RA.
Related Products of 17557-76-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 17557-76-5 is helpful to your research.
Reference:
Isoquinoline – Wikipedia,
,Isoquinoline | C9H7N – PubChem