Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C10H13NO, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 63006-93-9
Synthetic investigations of (1,3?)-bistetrahydroisoquinolines: Towards pentacyclic analogues of piperazine core alkaloids
Synthetic investigations of (1,3?)-bistetrahydroisoquinolines are reported as the key intermediates for the synthesis of ecteinascidin and phthalascidin pentacyclic structure analogues through successive Pictet-Spengler cyclization and intramolecular peptide coupling. The direct Pictet-Spengler reaction between a derivative of l-DOPA and N-protected-alpha-aminoaldehyde was first extended to the synthesis of cis-(1,3?)- bistetrahydroisoquinoline. After introduction of the required amino acid moiety, an efficient six-membered ring intramolecular peptide coupling gave rise to piperazine derivative structures. Complete structural assignments were corroborated by NMR and X-ray spectroscopic methods. Nevertheless, the optical integrity of the N-protected-alpha-aminoaldehyde seems to be sensitive to the reaction conditions. Pentacylic structures, having an anti C3-C11 backbone stereochemistry, were obtained from cyclization para- and ortho- to the 3-OH group of the l-DOPA derivative.
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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem