Chemistry is an experimental science, HPLC of Formula: C14H12N2O4, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 17557-76-5, Name is 4,4′-Diamino-[1,1′-biphenyl]-2,2′-dicarboxylic acid, molecular formula is C14H12N2O4, belongs to isoquinoline compound. In a document, author is McNaught, KS.
Toxicity to PC12 cells of isoquinoline derivatives structurally related to 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine
Isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or 1-methyl-4-phenylpyridinium (MPP(+)) are inhibitors of mitochondrial function and substrates for the dopamine re-uptake system, but their neuronal toxicity is unclear, In this study, the effects of exposing PC12 cells to four isoquinoline derivatives (isoquinoline, N-methylisoquinolinium, 6,7-methylenedioxyisoquinoline and 1,2,3,4-tetrahydroisoquinoline) and MPP(+) (100-1000 mu M) were examined. All compounds exhibited concentration-dependent toxicity as determined by lactate dehydrogenase release, but none of the isoquinoline derivatives were more toxic than MPP(+). Cytotoxicity of these compounds appears to be directly correlated with their substrate affinity for the dopamine reuptake system, but not mitochondrial inhibition. Thus, the low toxicity of isoquinoline derivatives towards PC12 cells suggests that high concentrations of or prolonged exposure to these compounds may be necessary to cause the neurodegenerative changes related to Parkinson’s disease.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 17557-76-5, in my other articles. HPLC of Formula: C14H12N2O4.
Reference:
Isoquinoline – Wikipedia,
,Isoquinoline | C9H7N – PubChem