Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 521284-21-9, Name is (R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol hydrochloride, molecular formula is C16H19ClN2O3, belongs to isoquinoline compound, is a common compound. In a patnet, author is Strupinska, Marzanna, once mentioned the new application about 521284-21-9, Application In Synthesis of (R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol hydrochloride.
SYNTHESIS AND STUDY OF SUBSTITUTED AMIDES OF ISOQUINOLINE-3-AND ISOQUINOLINE-1-CARBOXYLIC ACIDS AS POTENTIAL ANTICONVULSANTS
Previously obtained benzylamides of isoquinoline-3-carboxylic acids and isoquinoline-l-carboxylic acids exhibited anticonvulsant activity. In search for more effective anticonvulsants, a series of amides of isoquinoline-3- and isoquinoline-1-carboxylic acids have been synthesized (1-9). The obtained compounds were evaluated qualitatively for their anticonvulsant activity in the maximal electroshock seizure test (MES test), minimal clonic seizure test (6Hz test) and subcutaneous metrazol seizure threshold test (sc MET test) as well as in the rotorod neurotoxicity test (Tox test). One selected compound was tested quantitatively in 6Hz-test in mice after intraperitoneal administration and showed activity ED50 = 385.69 mg/kg and TD50 > 600 mg/kg (1).
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Reference:
Isoquinoline – Wikipedia,
,Isoquinoline | C9H7N – PubChem