With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.
Powdered isoquinoline-5-sulfonyl chloride hydrochloride (1.00 g, 3.79 mmol) is added in small portions to a stirred solution of tert-butylamine (2.00 mL, 18.9 mmol) in CHIC12 (10 mL) at 0 C under nitrogen. The resultant mixture is allowed to stir at ambient temperature for 1 hour. Ethyl acetate (50 mL) is added to the mixture and the mixture is washed with saturated aqueous NAHCO3 (20 mL). The organic layer is dried over MGS04, filtered and concentrated. The crude product is chromatographed on silica (gradient 0-2% CH30H in CH2C12) to give 857 mg (3.24 mmol, 86% yield) of the title compound as a white solid. ESIMS : m/z 265 (M+H) +. Analysis for C13HL6N202S : calcd : C, 59.07 ; H, 6.10 ; N, 10.60 ; found: C, 59.21 ; H, 6.01 ; N, 10.67.
105627-79-0, The synthetic route of 105627-79-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/94386; (2004); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem