With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19493-45-9,3-Chloroisoquinoline,as a common compound, the synthetic route is as follows.
EXAMPLE 1 This example illustrates the preparation of 3-chloro-5-nitro-isoquinoline having the formula: SPC6 3-chloro-isoquinoline (16.35 g., 0.1 mole) was dissolved in concentrated sulphuric acid (80 ml) and the solution was cooled to approximately 5C in an ice-water bath. Potassium nitrate (11 g. 0.11 mole) was dissolved in concentrated sulphuric acid (60 ml), the solution was cooled to approximately 5C and added dropwise, with stirring, over a period of 2 hours to the 3-chloro-isoquinoline solution, the temperature of the reaction mixture being maintained in the region of from 3 to 8C by means of the ice-water bath. The bath was then removed and the mixture stirred for a further 2 hours, and allowed to stand overnight. Next day the reaction mixture was poured into a water (800 ml)-ice (800 g.) mixture, and 3-chloro-5-nitro-isoquinoline precipitated as fine white crystals. The precipitate was filtered off, slurried with water, filtered again, washed thoroughly with water, and then recrystallized from a 3:1 v/v mixture of ethanol/acetone to yield 16.33 g. of 3-chloro-5 -nitro-isoquinoline of melting point 163 – 164C., 19493-45-9
19493-45-9 3-Chloroisoquinoline 640968, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; ICI Australia Limited; US3930837; (1976); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem