With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59139-93-4,2-(1-Oxoisoquinolin-2(1H)-yl)acetic acid,as a common compound, the synthetic route is as follows.,59139-93-4
General procedure: A suspension of carboxylic acid 6a (168mg, 0.77mmol) in dry CH2Cl2 was cooled to-5C and HOBt was added (250mg, 1.85mmol). After 20min, the reaction mixture was further cooled to-15C and treated with EDC¡¤HCl (355mg, 1.85mmol). Finally, a cold solution of pinandiol l-leucine boronate trifluoroacetate salt 7 in dry CH2Cl2 (292mg, 0.77mmol) and DIPEA (160muL, 0.92mmol) were added in sequence and the reaction mixture was stirred at-15C for 1h and then at room temperature for 2h. Then, the organic layer was washed with 0.1M KHSO4, 5% NaHCO3, and brine, dried over Na2SO4, filtered, and finally evaporated to give a crude that was triturated in Et2O and filtered, to afford the amide by-product ( 9a) as a solid. The ether solution was evaporated to give crude 8a which was used in the next reaction without further purification (293mg, 82%)
The synthetic route of 59139-93-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Troiano, Valeria; Scarbaci, Kety; Ettari, Roberta; Micale, Nicola; Cerchia, Carmen; Pinto, Andrea; Schirmeister, Tanja; Novellino, Ettore; Grasso, Silvana; Lavecchia, Antonio; Zappala, Maria; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 1 – 14;,
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