Reference of 19493-44-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.19493-44-8, Name is 1-Chloroisoquinoline, molecular formula is C9H6ClN. In a Article，once mentioned of 19493-44-8
Synthesis of bulky and electron-rich MOP-type ligands and their applications in palladium-catalyzed C-N bond formation
A series of 2-dialkylphosphino-2?-alkoxy-1,1?-binaphthyl ligands (6a-c and 8a-c) have been prepared conveniently by a lithium-initiated ring-opening reaction of dinaphthofuran, followed by selective phosphorylation. These compounds displayed a remarkable air and moisture stability, both in solid form and in solution. Application of these phosphine ligands in palladium-catalyzed C-N bond forming reactions revealed the crucial roles of the steric bulk of the substituents on the phosphorus atom governing the catalytic activity. Specifically, 2-di-tert-butylphosphino-2?-isopropoxy-1,1?- binaphthyl (8b) proved to be the most effective for the aminations of aryl halides with primary amines, while the less bulky 2-dicyclohexyl-2?- methoxy-1,1?-binaphthyl (6a) was more effective for the aminations with secondary amines. The steric and electronic effects of the ligands were analyzed to account for these observations.
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H1508N – PubChem