With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7651-81-2,Isoquinolin-3(2H)-one,as a common compound, the synthetic route is as follows.
Isoquinolin-3-ol was reacted with 2,3-dichloro-5-nitro pyridine in dry DMF and CS2CO3as base at room temperature to obtain 3-(3-chloro-5-nitropyridin-2-yloxy)isoquinoline which was further converted to 5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine by reaction with stannous chloride dehydrate as reducing agent at room temperature to obtain 5-chloro-6- (isoquinolin-3-yloxy)pyridin-3-amine., 7651-81-2
Big data shows that 7651-81-2 is playing an increasingly important role.
Reference£º
Patent; PIRAMAL ENTERPRISES LIMITED; ENOSE, Arno, Appavoo; WO2013/117963; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem