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Enantioselective dearomatization of isoquinolines by anion-binding catalysis en route to cyclic alpha-aminophosphonates
An enantioselective dearomatization of isoquinolines has been developed using chiral anion-binding catalysis. This transformation, catalyzed by a simple and easy to prepare tert-leucine-based thiourea derivative, makes use of silyl phosphite as a nucleophile and generates cyclic alpha-aminophosphonates. This is the first time asymmetric anion-binding catalysis has been applied to the synthesis of alpha-aminophosphonates.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 55270-33-2, you can also check out more blogs about55270-33-2
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem