171049-41-5, Name is tert-Butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate, belongs to isoquinoline compound, is a common compound. Quality Control of tert-Butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylateIn an article, once mentioned the new application about 171049-41-5.
Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11 Beta-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11 Beta-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human- derived 11 Beta-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.
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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem