With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80278-67-7,Isoquinoline-5-carbaldehyde,as a common compound, the synthetic route is as follows.
80278-67-7, General procedure: General procedure (14): In a dry sealed tube, a quinoline/isoquinoline-carboxaldehyde derivative (1.0 equiv) and a gramine derivative (1.0 equiv) were dissolved in anhydrous acetonitrile (3 mL for 0.530 mmol of gramine derivative). Tributyllphosphine (2.25 equiv) was added and the sealed reaction was heated at 90 ¡ãC in an oil bath for 22 h. After the reaction was allowed to cool to room temperature, the solvent was removed under vacuum. The crude material was washed with methanol and diethyl ether to afford the alkene product as a yellow precipitate which was filtered and dried under vacuum. Chemical Example 25 5-((E)-2-(1/-/-indol-3-vl)vinyl)isoquinoline Compound 25 [a166] (40 mg, 0.148 mmol) was prepared as a yellow solid from Intermediate 23 (92 mg, 0.530 mmol) and isoquinoline-5-carboxaldehyde (83 mg, 0.530 mmol) according to general procedure (14). Yield: 28percent. 1H NMR (400 MHz, Acetone) delta: 10.57 (s, 1 H), 9.28 (d, J = 0.8 Hz, 1 H), 8.56 (d, J = 6.0 Hz, 1 H), 8.22 (d, J = 6.0 Hz, 1 H), 8.17 – 8.11 (m, 2H), 7.98 (d, J = 8.2 Hz, 1 H), 7.90 (d, J = 16.2 Hz, 1 H), 7.78 (d, J = 2.5 Hz, 1 H), 7.69 (t, J = 7.7 Hz, 1 H), 7.62 (d, J = 16.2 Hz, 1 H), 7.53 – 7.47 (m, 1 H), 7.29 – 7.14 (m, 2H). 13C NMR (100 MHz, Acetone) delta: 154.07, 151.28, 147.70, 143.48, 138.48, 136.75, 129.59, 128.49, 127.67, 126.60, 124.40, 123.17, 121.19, 120.89, 116.74, 116.54, 115.67, 112.82. LC-MS (ESI): m/z 272.1 [M + H]+.
The synthetic route of 80278-67-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NATIONAL UNIVERSITY OF SINGAPORE; LEE, Sang Hyun; DYMOCK, Brian William; KITAGAWA, Mayumi; SEE, Cheng Shang; (178 pag.)WO2016/200339; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem