23687-25-4,23687-25-4, Isoquinolin-4-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 76; N-(Isoquinolin-4-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide; (1) 2,2,2-Trichloroethyl isoquinolin-4-ylcarbamate; To a solution of 3-aminoisoquinoline (1.00 g; 6.94 mmol) and pyridine (0.660 ml, 8.32 mmol) in tetrahydrofuran (23 ml) was added, under ice-cooling, 2,2,2-trichloroethyl chloroformate (1.15 ml, 8.32 mmol), and the mixture was stirred at room temperature for 1 hour and half. Water was poured to the reaction mixture, and the resulting solution was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. Hexane was poured to the residue, and 2.03 g (91.7%) of the desired product as a solid was separated by filtration. 1H-NMR (DMSO-d6) delta; 5.01 (2H, s), 7.54 (1H, t, J = 7.8 Hz), 7.72 (1H, t, J = 7.8 Hz), 7.91 (1H, d, J = 7.8 Hz), 8.06 (1H, d, J = 8.1 Hz), 8.17 (1H, s), 9.15 (1H, s).
The synthetic route of 23687-25-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1813606; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem