With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23687-25-4,Isoquinolin-4-amine,as a common compound, the synthetic route is as follows.
Example 1071-[(2-Chloro-4-fluorophenyl)methyl]-4-(4-isoquinolinyl)-2,3-piperazinedione(E107)Methyl [[(2-chloro-4-fluorophenyl)methyl](2-oxoethyl)amino](oxo)acetate (0.40 g, 1.39 mmol, prepared as described earlier), 4-aminoisoquinoline (0.40 g, 2.78 mmol) and acetic acid (0.08 ml, 1.39 mmol) were dissolved in 1 ,2-dichloroethane (20 ml) and stirred for 10 minutes. Polymer-supported cyanoborohydride (1.74 g, 6.95 mmol) was added and the reaction stirred at room temperature for approximately 64 hours. The reaction was then heated to reflux at 850C for 7 hours. The reaction mixture was then concentrated in vacuo and redissolved in 1-butanol (3 ml). The solution was heated to 16O0C for 1 hour in the microwave. The mixture was concentrated in vacuo and purified by flash-silica gel chromatography. The mixture was eluted with ethyl acetates followed by 5% methanol in dichloromethane and finally 10% methanol in dichloromethane. Clean product fractions were combined and concentrated in vacuo to give a brown oil, which was triturated with a mixture of diethyl ether (10 ml) and methanol (2 ml) to yield 1-[(2-chloro-4-fluorophenyl)methyl]-4-(4-isoquinolinyl)-2,3- piperazinedione (0.032 g) as a cream-coloured solid. LC/MS [M+H]+ = 384, retention time = 2.29 minutes.
As the paragraph descriping shows that 23687-25-4 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; CHAMBERS, Laura Jane; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; STEADMAN, Jon Graham Anthony; WALTER, Daryl Simon; WO2010/125103; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem