18881-17-9, (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,18881-17-9
j.jcpation2.e: tert-Butyl [(35)-I ,2,3,4-tctrahydroisoquinoIin-3-yImetby1carbamateStep A: Benzj?t (3S)-3(IsydroxymetIiy1)-3,4-diJiydro-1H-isoquinoIine-2-carboxyhnte This compound is obtained using a protocol from the literature (K B. Kawthekar ci at South Africa Journal of Chernistiy 63, 195, 2009) starting from 15 g of (3S-1,2,3,4- tetrahydroisoquinolin-3-ylmethanol (91.9 mmol) in the presence of benzyl chloroformate and triethylamine dissolved in dichloromethane. After purification on silica gel (gradientpetroleum ether AcOEt), the title product is obtained in the form of an oil.?11 NMR: oe (300 MHz; DMSO-d6; 300K): 7.33 (m, 511, aromatic Hs, O-benzyl); 7.15 (s,4H, aromatic Hs, H tetrahydroisoquinofine); 5.13 (s, 2H, C112-Ph); 4.73 (d, 11-1, Htetrahydroisoquinoline); 4.47 (m, H, CH2OH); 4.36 (m, 1H, H tetrahydroisoquinoline);4.28 (d, TH, H tetrahydroisoquinoline); 3.39 (dd, 1H, CH2OH); 3.23 (dd, lH, CU2OH);2.93 (dd, I H, I-I tetrahydroisoquinoline); 2.86 (dd, IH, H tetrahydroisoquinoline). IR: v OH: 3416 ciii?; v C-H: 754 cm1
The synthetic route of 18881-17-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; DAVIDSON, James, Edward, Paul; MURRAY, James, Brooke; CHEN, I-Jen; WALMSLEY, Claire; DODSWORTH, Mark; MEISSNER, Johannes, W., G.; BROUGH, Paul; FEJES, Imre; TATAI, Janos; NYERGES, Miklos; KOTSCHY, Andras; SZLAVIK, Zoltan; GENESTE, Olivier; LE TIRAN, Arnaud; LE DIGUARHER, Thierry; HENLIN, Jean-Michel; STARCK, Jerome-Benoit; GUILLOUZIC, Anne-Francoise; DE NANTEUIL, Guillaume; WO2015/11164; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem