With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.622867-52-1,tert-Butyl 6-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.,622867-52-1
Example 4: [6-Dimethylaminomethyl-3,4-dihydro-2( 1 H)isoquinolin-2-yl]( 1 -methyl- 1 H-indol-2-yl)methanone:(1) Production of 1,1-dimethylethyl 6-(t-butyldiphenylsilyloxymethyl)-3,4-dihydro-2(lH)- isoquinolinecarboxylate: T-butyldiphenylchlorosilane (557 mg, 2.03 mmol) and imidazole (288 mg, 4.22 mmol) were added in an N,N-dimethylformamide (6 mL) solution of 1,1-dimethylethyl 3,4-dihydro-6- (hydroxymethyl)-2(lH)-isoquinolinecarboxylate (445 mg, 1.69 mmol), and the mixture was stirred overnight at room temperature. The reaction liquid was diluted with ethyl acetate (20 mL), and washed with water and saturated brine. The organic layer was dried with magnesium sulfate, and the solvent was evaporated off under reduced pressure. The residue was purified through silica gel column chromatography to give the entitled compound (975 mg, 100 %) as a colorless oil.
622867-52-1 tert-Butyl 6-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 59132278, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; BANYU PHARMACEUTICAL CO.,LTD.; HAGA, Yuji; MIZUTANI, Sayaka; SATO, Nagaaki; WO2010/126164; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem