82827-09-6, 6-Bromoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
82827-09-6, To a solution of 6-bromoisoquinolin-1(2H)-one (0.5 g, 2.23 mmol) in DMA (10 mL), wasadded NaH (60%, 0.13 g, 3.34 mmol) at room temperature and the mixture was stirred for 30mi 4-methoxybenzyl chloride (0.52 g, 3.34 mmol) was added to the reaction mixture at room temperature. The reaction mixture was stirred at rt for 3 h. Progress of the reaction was monitored by TLC. The reaction mixture was diluted with water (100 mL) and extracted with EtOAc (2 x 50 mL). The organic layers were separated, dried (Na2SO4), filtered and concentratedto afford 130 (1.02 g, crude) as a brown semisolid. This material was used for the next step without further purification. MS (ESl + ye): 344.04. 1H-NMR (400 MHz; DMSO-d6): oe 8.12 (d, J = 8.56 Hz, 1H), 7.94 (s, 1H), 7.65-7.62 (m, 2H), 7.30-7.26 (m, 2H), 6.91-6.87 (m, 2H), 6.61 (d, J = 7.32 Hz, 1H), 5.08 (s, 2H), 3.72 (s, 3H).
The synthetic route of 82827-09-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CARDIO THERAPEUTICS PTY LTD; TREUTLEIN, Herbert; ZENG, Jun; DIXON, Ian; JAMES, Ian; PALMER, James T; (169 pag.)WO2018/165718; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem