With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90806-60-3,5-Methoxyisoquinoline-1-carbonitrile,as a common compound, the synthetic route is as follows.
[00244] Cap-138, Step c (0.45 g, 2.44 mmol) was treated with 5N sodium hydroxide solution (10 mL) and the resulting suspension was heated at 85 C for 4 h, cooled to 25 C, diluted with dichloromethane and acidified with IN hydrochloric acid. The organic phase was separated, washed with brine, dried over Na2S04, concentrated to ? volume and filtered to afford Cap-138 as a yellow solid (0.44g, 88.9%). XH NMR (DMSO-d6, 400 MHz) delta 13.6 (br s, 1H), 8.56 (d, J= 6.0 Hz, 1H), 8.16 (d, J = 6.0 Hz, 1H), 8.06 (d, J = 8.8 Hz, 1H), 7.71-7.67 (m, 1H), 7.30 (d, J= 8.0 Hz, 1H), 4.02 (s, 3H); Rt = 0.70 min (Cond.-Dl); 95% homogenity index; LC-MS: Anal. Calc. for [M+H]+ CnH10NO3:204.07; found: 204.05.
As the paragraph descriping shows that 90806-60-3 is playing an increasingly important role.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; ROMINE, Jeffrey, Lee; NGUYEN, Van, N.; WANG, Gan; LOPEZ, Omar, D.; ST. LAURENT, Denis, R.; CHEN, Qi; BENDER, John, A.; YANG, Zhong; HEWAWASAM, Piyasena; XU, Ningning; MEANWELL, Nicholas, A.; EASTER, John, A.; SU, Bao-Ning; SMITH, Michael, J.; WO2011/75439; (2011); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem