18881-17-9, (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,18881-17-9
Bis acid 9 (4.29 g, 9.2 mmol) was dissolved in dichloromethane (31 mL), and DIEA (4.8 mL, 27.6 mmol) was added followed by HATU (9.09 g, 23.9 mmol). Mixture was stirred for 30 minutes and (S)-(1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol (3.60 g, 22.1 mmol) was added at once. Reaction mixture was allowed to stir overnight, then washed with 0.5 M HCl, saturated NaHCO3 and concentrated to dryness. The residue was purified on 220 g silica Teledyne Isco column (05% MeOH in DCM). Evaporation of product containing fractions afforded 6.0 g of 10 (86% yield).1H NMR (500 MHz, DMSO-d6) = 7.77 (br. s., 2 H), 7.28 – 7.25 (m, 1 H), 7.24 – 7.16 (m, 8 H), 7.13 (br. s., 1 H), 6.98 (d, J = 7.8 Hz, 2 H), 5.33 (d, J = 16.1 Hz, 1 H), 5.01 – 4.88 (m, 2 H), 4.34 – 4.25 (m, 8 H), 3.91 (s, 6 H), 3.43 (br. s., 2 H), 3.27 – 3.21 (m, 2 H), 3.00 (d, J = 1.5 Hz, 1 H), 3.03 – 2.97 (m, 1 H), 2.76 (d, J = 2.9 Hz, 1 H), 2.29 (t, J = 6.1 Hz, 2 H). LC/MS: retention time 2.96 min. (ESI) C39H41N4O12 calculated for [M+H] + 757; found 757.
The synthetic route of 18881-17-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CELLERANT THERAPEUTICS, INC.; JUNUTULA, Jagath R.; JAMMALAMADAKA, Vasu; ZHU, Jianyu; (229 pag.)WO2018/53552; (2018); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem