164148-92-9, tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation of intermediate 235 was performed via 2 reactions as reported below.Reaction 1: N-bromosuccinimide (716 mg; 4.03 mmol) was added portionwise at 0C to a solution of t-Butyl-6-amino-3,4-dihydroisoquinoline-2-carboxylate (1 g; 4.03 mmol) inDCM (20 mL). The reactiocn mixture was stirred at room temperature for 2 hours, poured onto a 10% aqueous solution of K2C03 and extracted with DCM.Reaction 2: N-bromosuccinimide (2.08 g; 11.68 mmol) was added portionwise at 0C to a solution of t-Butyl-6-amino-3,4-dihydroisoquinoline-2-carboxylate (2.9 g; 11.68 mmol) inC (60 mL). The reaction mixture was stirred at room temperature for 2 hours, poured onto a 10% aqueous solution of K2C03 and extracted with DCM.The two residues were combined and purified by chromatography over silica gel (irregular SiOH, 80g; mobile phase: gradient from 20% EtOAc, 80% heptane to 40% EtOAc, 60%hetptane). The pure fractions were collected and evaporated to dryness yielding 2.8 g (54%) of intermediate 235.
164148-92-9, 164148-92-9 tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate 2756371, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier, Alexis, Georges; LIGNY, Yannick, Aime, Eddy; GROSS, Gerhard, Max; JACOBY, Edgar; MEERPOEL, Lieven; GREEN, Simon, Richard; HYND, George; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; (419 pag.)WO2018/2219; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem