With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151004-88-5,(R)-N-Cbz-3,4-dihydro-1H-isoquinolinecarboxylic acid,as a common compound, the synthetic route is as follows.
To N-Benzyloxycarbonyl-D-1,2, 3, 4-tetrahydro-isoquinoline-1-carboxylic acid (3.11 g, 10 mmol, made from commercially available D-1,2, 3, 4-tetrahydro- ISOQUINOLINE-1-CARBOXYLIC acid and O-BENZYLOXYCARBONYL-N-HYDROXYSUCCINAMIDE) in THF (10 mL) was added BH3 (1M solution in THF; 30 mL, 30 mmol) over 5 min, and the reaction mixture was stirred for 3 hours. Acetic acid (9 mL) in MEOH (90 mL) was added and the mixture was stirred for 30 min. Solvents were evaporated, the residue was taken up in EtOAc and was washed with saturated aqueous NAHC03 (90 mL, aq. phase pH 7-8) and brine. The organic layer was dried over NA2S04 and concentrated to give compound 13a (2.97 g, 100%). MS (CI) M/Z 253.9 (MH+-CO2), 297. 9 (MH+) ; TR = 2.695 min (method 4)., 151004-88-5
The synthetic route of 151004-88-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/7164; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem