With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18881-17-9,(S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol,as a common compound, the synthetic route is as follows.,18881-17-9
Compound 2 (5.3 g, 16.47 mmol) and (S)-(1,2,3,4-tetrahydroisoquinolin-3-yl)methanol (2.96 g, 18.12 mmol) were dissolved in DCM (47.1 mL). The reactionmixture was cooled to 0 oc and TEA (3.44 mL, 24.71 mmol) was added dropwise underAr. The reaction mixture was then warmed to rt and was stirred overnight. The solutionwas concentrated and the crude product was purified by silica gel chromatography(EtOAc/hexanes, gradient, 0% to 80%) to obtain compound 3 (7.22 g, 16.10 mmol, 98% yield). LCMS = 5.482 min (8 min method). Mass observed (ESI+): 449.25 (M+H).
The synthetic route of 18881-17-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; (163 pag.)WO2018/195243; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem