6624-49-3, Name is Isoquinoline-3-carboxylic acid, belongs to isoquinoline compound, is a common compound. name: Isoquinoline-3-carboxylic acidIn an article, once mentioned the new application about 6624-49-3.
The structure-activity relationship of the boronic acid derivatives of tyropeptin, a proteasome inhibitor, was studied. Based on the structure of a previously reported boronate analog of tyropeptin (2), 41 derivatives, which have varying substructure at the N-terminal acyl moiety and P2 position, were synthesized. Among them, 3-phenoxyphenylacetamide 6 and 3-fluoro picolinamide 22 displayed the most potent inhibitory activity toward chymotryptic activity of proteasome and cytotoxicity, respectively. The replacement of the isopropyl group in the P2 side chain to H or Me had negligible effects on the biological activities examined in this study.
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem