With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27655-40-9,Isoquinoline-5-sulfonic acid,as a common compound, the synthetic route is as follows.
The solution of isoquinoline-5-sulfonic acid 1b (4.0 g, 0.019 mol) in 25 mL thionyl chloride and 0.1 mL dimethylformamide was heated to reflux for 2 h. The mixture was then distilled under reduced pressure to remove unreacted thionyl chloide. The crude was washed by dichloromethane (10 mL*2), and air dried to give isoquinoline-5-sulfonyl chloride 1e (3.9 g, yellow solid, yield: 100%). MS-ESI cal. [M+H]+ 227, found 227., 27655-40-9
27655-40-9 Isoquinoline-5-sulfonic acid 241599, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; MEDSHINE DISCOVERY INC.; WU, Lingyun; YAO, Yuanshan; CHEN, Zhaoguo; CHEN, Shuhui; (69 pag.)US2017/37050; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem