Some tips on 106778-43-2

106778-43-2, The synthetic route of 106778-43-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106778-43-2,6-Isoquinolinecarboxylic Acid,as a common compound, the synthetic route is as follows.

[00191] Isoquinoline-6-carbohydrazide: Isoquinoline-6-carboxylic acid (1.2 g,6.94 mmol) purchased from Gateway Chemical Technology, Inc. was mixed with CDI (1.68 g, 10.4 mmol) in DMF (20 Ml) in a round bottom flask. After the mixture was stirred for 30 minutes at 2O0C, anhydrous hydrazine (2 mL) was added and the resulting mixture was stirred at 2O0C for one hour. After removing the solvent at a reduced pressure, the remaining residue was mixed with 20 mL water. After filtration, washing with water and air drying, an off-white solid was obtained as the desired product. LCMS (API-ES) m/z (%): 188.0 (100%, M++H).

106778-43-2, The synthetic route of 106778-43-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2009/11880; (2009); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem