With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-84-9,Isoquinolin-1-amine,as a common compound, the synthetic route is as follows.
EXAMPLE 6 2-[(1,1′-Biphenyl)-4-yl]-imidazo[2,1-a]isoquinoline A solution of 4.32 g. (0.03 mole) of 1-amino-isoquinoline and 8.25 g. (0.03 mole) of [(1,1′-biphenyl)-4-yl]-bromomethyl-ketone in 100 ml. of chloroform was heated on a boiling water bath for about 10 minutes until a precipitate separated. The solvent was distilled off at atmospheric pressure and the residue was heated under vacuum for 30 minutes at 100 C. It was subsequently taken up with 50 ml of water and the resulting solution was made alkaline by means of 70 ml. of aqueous 10% sodium hydroxide. After extracting with 500 ml. of methylene chloride and evaporating the solvent, a residue was obtained which was re-crystallized from ethylene glycol monomethylether. Yield 3.0 g. M.p. 221-22 C., 1532-84-9
As the paragraph descriping shows that 1532-84-9 is playing an increasingly important role.
Reference：
Patent; Gruppo Lepetit S.p.A.; US4275066; (1981); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem