With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.104704-40-7,4-Bromo-1-methylisoquinoline,as a common compound, the synthetic route is as follows.
Example No. 130Preparation of Compound No. 164[0427] A solution of 2, 8-dimethyl-2, 3, 4, 5-tetrahydro-lH-pyrido[4,3-b]indole (310 mg, 1.55 mmol), K3P04 (0.985 g, 4.65 mmol), Cul (29.4 mg, 0.15 mmol), L-proline (35.6 mg, 0.31 mmol) and 4-bromo-l-methylisoquinoline (0.520 g, 2.35 mmol) in dry DMF (3 mL) was stirred at RT for 10 min and then at 150 C for 16h. Water (50 mL) was added to the reaction mixture and then extracted with EtOAc (150 mL). The organic layer was washed with water (6×30 mL), dried over anhydrous sodium sulfate and evaporated to afford crude material, which was purified by reverse phase HPLC to yield 2,8-dimethyl-5-(l-methylisoquinolin-4- yl)-2,3,4,5-tetrahydro-lH-pyrido[4,3-b]indole as the TFA salt. 1H NMR (CD3OD, TFA salt) d (ppm): 8.6-8.74 (m, 2H), 8.0 (m, 2H), 7.41 (s, IH), 7.38 (bs, IH), 7.0 (d, IH), 6.8 (bs, IH), 4.8 (bs, IH), 4.5 (bs, IH), 3.8 (bs, IH), 3.6 (bs, IH), 3.3 (s, 3H), 3.18 (s, 3H), 3.0 (bs, IH), 2.82 (bs, IH), 2.41 (s, 3H)., 104704-40-7
104704-40-7 4-Bromo-1-methylisoquinoline 613570, aisoquinoline compound, is more and more widely used in various fields.
Reference：
Patent; MEDIVATION TECHNOLOGIES, INC.; CHAKRAVARTY, Sarvajit; HART, Barry, Patrick; JAIN, Rajendra, Parasmal; WO2011/103430; (2011); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem