The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine, is researched, Molecular C12H10N6, CAS is 1671-88-1, about Mono- and polynuclear complexes of Pt(II) with polypyridyl ligands, the main research direction is platinum complex pyridyl nitrogen heterocycle preparation antitumor activity.Related Products of 1671-88-1.
An array of poly- and mononuclear complexes of Pt(II) with polypyridyl ligands is reported. The framework complexes [(PtCl2)2(bpp)2(μ-PtCl2)](H2O)2 [bpp = 2,3-bis(2-pyridyl)pyrazine], [PtCl2(μ-tptz)PtClNCPh]Cl [tptz = 2,4,6-tris(2-pyridyl)-1,3,5-triazine], and mononuclear PtCl2(NH2dpt) [NH2dpt = 4-amino-3,5-bis(2-pyridyl)-1,2,4-triazole] were prepared and structurally characterized by IR and NMR spectroscopies. Both neutral and ionic complexes are present, with bifunctional and monofunctional Pt(II) moieties, whose size and shape enable them to behave as novel scaffolds for DNA binding. Pt(II) complexes were tested for their biol. activity. Cell viability assay and flow cytometric anal. demonstrated that these complexes, particularly [PtCl2(μ-tptz)PtClNCPh]Cl, were effective death inducers in human colon rectal carcinoma HT29 cells and their cytotoxic activity was higher than that exerted by cisplatin. Morphol. anal. of treated HT29 cells, performed by fluorescence microscopy after Hoechst 33258 staining, showed the appearance of the typical features of apoptosis. Also, results suggested that mitochondria are involved in apoptosis induced by Pt(II) complexes in HT29 cells as demonstrated by dissipation of mitochondrial transmembrane potential.
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Isoquinoline – Wikipedia,
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