So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jeyaveeran, J. C.; Praveen, Chandrasekar; Arun, Y.; Prince, A. A. M.; Perumal, P. T. researched the compound: Methyl 5-methoxyindole-2-carboxylate( cas:67929-86-6 ).Quality Control of Methyl 5-methoxyindole-2-carboxylate.They published the article 《Flexible synthesis of isomeric pyranoindolones and evaluation of cytotoxicity towards HeLa cells》 about this compound( cas:67929-86-6 ) in Journal of Chemical Sciences (Berlin, Germany). Keywords: pyranoindolone anticancer agent cytotoxicity cervix adenocarcinoma. We’ll tell you more about this compound (cas:67929-86-6).
A hybrid pharmacophore approach for the synthesis of isomeric pyranoindolones was achieved by employing gold(III) chloride-catalyzed cycloisomerization of alkyne-tethered indole carboxylic acids in good to excellent yield. All the synthesized compounds were evaluated for their tumor cell growth inhibitory activity against human cervix adenocarcinoma (HeLa) which revealed that three compounds exhibited activity comparable with the standard cis-platin (IC50 = 0.08 μM). Mol. docking of all the compounds in Vaccinia H1-Related (VHR) Phosphatase receptor also supported that compound 7d as the most active with a free energy of binding as -8.27 kcal/mol. [Figure not available: see fulltext.].
As far as I know, this compound(67929-86-6)Quality Control of Methyl 5-methoxyindole-2-carboxylate can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem