The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Methyl 5-methoxyindole-2-carboxylate, is researched, Molecular C11H11NO3, CAS is 67929-86-6, about Synthesis, biological evaluation and molecular docking studies of 2-amino-3,4,5-trimethoxyaroylindole derivatives as novel anticancer agents, the main research direction is aminotrimethoxyaroylindole preparation anticancer agent; indole aminotrimethoxy preparation anticancer agent; 2-Amino-3,4,5-trimethoxyaroylindole; Anticancer; Combretastatin A-4; Synthesis.Category: isoquinoline.
A series of novel 2-amino-3,4,5-trimethoxyaroylindole derivatives was synthesized and evaluated against selected human cancer cell lines of breast (MCF-7) and colon (HT-29). Introduction of an amino group at the C-2 position on ring A of 3,4,5-trimethoxyaroylindole derivatives resulted in novel compounds, i.e., 2-amino-3,4,5-trimethoxyaroylindole derivatives exhibiting excellent cytotoxic activity against human cancer cell lines. Substitution with a methoxy group at R6 in 2-amino-3,4,5-trimethoxyaroylindole (I) exhibited excellent cytotoxic activity against MCF-7 (0.013 μM) and colon HT-29 (0.143 μM) indicating slightly higher potency than Combretastatin A-4. Mol. modeling studies of 2-amino-3,4,5-trimethoxyaroylindole derivatives have similar structural alignment as colchicine in protein (PDB code: 1SA0) and exhibited hydrogen bond interaction between para position of 3,4,5-trimethoxyphenyl ring with CYS 241 and N-H mol. of indole ring with Val 315 of receptor mol.
As far as I know, this compound(67929-86-6)Category: isoquinoline can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem