The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid(SMILESS: OC(=O)C1=NN(C(=C1)C1=CC=CC=C1)C1=CC=CC=C1,cas:13599-22-9) is researched.Recommanded Product: 1-Bromo-2-pentyne. The article 《Esters of oxo acids of acetylene series. VI. Reaction of the esters of phenylethynylglyoxalic acid with hydrazine, hydrazide, and hydroxylamine》 in relation to this compound, is published in Zhurnal Organicheskoi Khimii. Let’s take a look at the latest research on this compound (cas:13599-22-9).
cf. CA 65, 10523b. Addition of N2H4.H2O to Et phenylethynylglyoxalate in EtOH gave 75% Et 3-phenylpyrazole-5-carboxylate, m. 139.5°; similarly were prepared: Pr ester, m. 110°; iso-Pr ester, m. 164°. Addition of RNHNH2 in Et2O to the appropriate ester of phenylethynylglyoxalic acid gave the following esters of 4-arylhydrazino-4-phenyl-3-buten-2-on-1-oic acids, RNHNHCPh:CCOCO2R’ (R and R’ shown, resp.): Ph, Et, 32%, m. 83°; Ph, iso-Pr (I) 65%, m. 124.5°; p-MeC6H4, iso-Pr, 32%, m. 77°; 0-MeC6H4, iso-Pr, 55%, m. 72.5°; Bz, iso-Pr (II) 87%, m. 125.5°; 0-O2NC6H4CO, iso-Pr, 78%, m. 137°; m-O2NC6H4CO, iso-Pr, 83%, m. 181°; p-O2NC6H4CO, iso-Pr, 88%, m. 175°. II heated in AcOH 2 hrs. gave 93% 1,5-diphenylpyrazole-3-carboxylic acid iso-Pr ester, m. 86.5-7°. I heated with aqueous alc. KOH 20 min. gave 1,5-diphenylpyrazole-3-carboxylic acid. Heating iso-Pr phenylethynylglyoxalate with HONH2.HCl in aqueous EtOH gave after addition of aqueous Na2CO3 over 9 hrs. 50% iso-Pr 3-phenylisoxazole-5-carboxylate, m. 65-6°. Similarly was prepared 29% Et 3-phenylisoxazole-5-carboxylate, m. 47°. Ir spectra were reported.
When you point to this article, it is believed that you are also very interested in this compound(13599-22-9)Recommanded Product: 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid and due to space limitations, I can only present the most important information.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem