Safety of (3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine, is researched, Molecular C37H33O4P, CAS is 147700-62-7, about Asymmetric conjugate addition to alkylidene malonates. Author is Alexakis, A.; Benhaim, C..
Dialkylzinc and trialkylaluminium reagents (alkyl = Me, Et, Bu) undergo conjugate addition to alkylidene malonates R1CH:C(CO2Et)2 (R1 = Me, n-Bu, Ph) with 0.5% copper triflate as catalyst. The reaction could be made enantioselective by completing the reaction in the presence of 0.5-1.0 mol% of chiral phosphorus ligand. Enantiomeric excesses (e.e.’s) of up to 73% could be attained with a ligand prepared from TADDOL and 2-naphthylcyclohexanol.
I hope my short article helps more people learn about this compound((3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine)Safety of (3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine. Apart from the compound(147700-62-7), you can read my other articles to know other related compounds.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem