In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Application of the Chiral Poisoning Strategy: Enantioselective Diels-Alder Catalysis with a Racemic Ru/BINAP-Monoxide Lewis Acid, published in 2002-04-15, which mentions a compound: 147700-62-7, mainly applied to chiral poisoning enantioselective Diels Alder methacrolein cyclopentadiene ruthenium catalysis; racemic ruthenium BINAP monoxide Lewis acid catalyst Diels Alder; methylbicyclo heptenecarboxaldehyde enantioselective preparation; asym Diels Alder methacrolein cyclopentadiene racemic ruthenium BINAP monoxide; proline prolinamide chiral poison ruthenium BINAP monoxide catalyst, Recommanded Product: 147700-62-7.
A chiral poisoning strategy has been applied to the [(±)-p-cymeneRuCl(BINPO)]SbF6 (±1) catalyst system for the asym. Diels-Alder reaction between methacrolein and cyclopentadiene to produce enantioenriched exo-2-methylbicyclo[2.2.1]hept-5-ene-2-carboxaldehyde. When ±1 was mixed with AgSbF6, the dicationic Lewis acid [(±)-p-cymeneRu(H2O)(BINPO)](SbF6)2 (±2) was generated. The additions of a number of chiral poisons (P* = enantiopure ligand) were found to deactivate one of the enantiomers of the catalyst with varied levels of selectivity. The most effective chiral poison was either L-proline or L-prolinamide. In catalytic trials with L-proline, an ee of up to 54% was observed In the case where a stoichiometric amount of (±)-Ru/methacrolein reacted in the presence of L-prolinamide, the DA product was obtained with ee = 60% (S), de = 96% (exo), and 92% conversion.
I hope my short article helps more people learn about this compound((3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine)Recommanded Product: 147700-62-7. Apart from the compound(147700-62-7), you can read my other articles to know other related compounds.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem