Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Bromo-3-methoxypyridin-2-amine, is researched, Molecular C6H7BrN2O, CAS is 42409-58-5, about An efficient, regioselective amination of 3,5-disubstituted pyridine N-oxides using saccharin as an ammonium surrogate.Product Details of 42409-58-5.
A process for the regioselective amination of unsym. 3,5-substituted pyridine N-oxides has been developed utilizing cheap, readily available saccharin as an ammonium surrogate. High conversions of the corresponding saccharin adducts have been achieved under mild reaction conditions. In situ deprotection under acidic conditions allows for a one-pot process to substituted aminopyridines. High regioselectivities were obtained from a variety of 3,5-disubstituted pyridine N-oxides.
In addition to the literature in the link below, there is a lot of literature about this compound(5-Bromo-3-methoxypyridin-2-amine)Product Details of 42409-58-5, illustrating the importance and wide applicability of this compound(42409-58-5).
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem