Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 67929-86-6, is researched, SMILESS is O=C(C(N1)=CC2=C1C=CC(OC)=C2)OC, Molecular C11H11NO3Journal, Chemistry Letters called Design and synthesis of two cytotoxic analogs of the novel pyrrolo[1′,2′:1,2][1,4]diazepin[7,6-b]indol-5(6H)-one nucleus, Author is Tsotinis, Andrew; Vlachou, Margarita; Kiakos, Konstantinos; Hartley, John A.; Thurston, David E., the main research direction is pyrrolodiazepinindolone preparation cytotoxicity leukemia antitumor agent; diazepinindolone pyrrolo preparation cytotoxicity leukemia antitumor agent; indolone pyrrolodiazepin preparation cytotoxicity leukemia antitumor agent.Category: isoquinoline.
The design and synthesis of the two cytotoxic derivatives I (R = H or MeO) of the novel pyrrolo[1′,2′:1,2][1,4]diazepin[7,6-b]indol-5(6H)-one nucleus is described. Readily available Me 2-indolecarboxylates underwent sequential nitrosation with NaNO2 in AcOH, oxidation with KMnO4 in aqueous NaOH, amidation with (2S)-pyrrolidine-2-carboxaldehyde di-Et thioacetal in the presence of EDCI and HOBt, nitro group reduction, and 7-exo-trig cyclization reaction to give the target mols. The new analogs were evaluated in the human leukemic K562 cell line and were shown to have micromolar potency.
This literature about this compound(67929-86-6)Category: isoquinolinehas given us a lot of inspiration, and I hope that the research on this compound(Methyl 5-methoxyindole-2-carboxylate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem