The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Methyl 5-methoxyindole-2-carboxylate(SMILESS: O=C(C(N1)=CC2=C1C=CC(OC)=C2)OC,cas:67929-86-6) is researched.SDS of cas: 67929-86-6. The article 《Synthesis and pharmacological evaluation of 6a,7-dihydro-6H,13H-pyrazino[1,2-a;4,5-a’]diindole analogs as melatonin receptor ligands》 in relation to this compound, is published in Tetrahedron. Let’s take a look at the latest research on this compound (cas:67929-86-6).
The synthesis of two melatonin-derived analogs of the novel 6a,7-dihydro-6H,13H-pyrazino[1,2-a;4,5-a’]diindole ring system was described. The non-methoxy and methoxy analogs, I (R = H or MeO) were prepared in seven steps starting from indoline-2-carboxylic acid and 5-methoxyindoline-2-carboxylic acid, resp. While I (R = H) exhibited micromolar affinities for both melatonin receptors, the methoxy analog I (R = MeO) displayed moderate affinity for MT2 receptors (K i=0.41 μM) being 4.4-fold higher than for the MT1 subtype.
In some applications, this compound(67929-86-6)Electric Literature of C11H11NO3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem