Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-(5-Bromothiophen-2-yl)pyridine, is researched, Molecular C9H6BrNS, CAS is 123784-07-6, about Synthesis, antibacterial activity and docking of 14-membered 9-O-(3-arylalkyl) oxime 11,12-cyclic carbonate ketolides.Quality Control of 2-(5-Bromothiophen-2-yl)pyridine.
A series of 9-O-(3-aryl-2-propargyl)oxime ketolides, e.g. I, was synthesized and evaluated for in vitro antibacterial activity and displayed dramatically improved potency against inducibly MLSB-resistant and efflux-resistant pathogens as compared to clarithromycin and azithromycin. I possessed an MIC of 0.064 μg/mL against constitutively MLSB-resistant Streptococcus pneumoniae, and MICs of 0.032-0.064 μg/mL against methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus hominis. A docking study was performed to gain insight into the binding mode of I to rationalize the disparity found in the SAR of I.
《Synthesis, antibacterial activity and docking of 14-membered 9-O-(3-arylalkyl) oxime 11,12-cyclic carbonate ketolides》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2-(5-Bromothiophen-2-yl)pyridine)Quality Control of 2-(5-Bromothiophen-2-yl)pyridine.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem