Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-(5-Bromothiophen-2-yl)pyridine, is researched, Molecular C9H6BrNS, CAS is 123784-07-6, about Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2.Category: isoquinoline.
The preparation of 4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines I [R = HOCH2C:C, (morpholinocarbonyl)ethynyl, (morpholinocarbonyl)ethenyl, 1,2-dihydro-5-oxoimidazol-3-yl, (morpholinocarbonyl)triazolyl, Me3SiC:C, PhC:C, 2-pyridylethynyl, Me3SiCH:CH, PhCH:CH, 2-pyridylethenyl, Me3SiCH2CH2, PhCH2CH2, 2-pyridylethyl, etc.] is described. I were tested for their activity as platelet-activating factor antagonists; I were compared to related compounds, e.g. WEB 2086, I [R = 2-(morpholinocarbonyl)ethyl], I (R = 4-BuC6H4C:C) and I (R = 4-Me2CHCH2C:C). The activity-structure relationship of I (R = substituted ethynyl) was investigated.
This compound(2-(5-Bromothiophen-2-yl)pyridine)Category: isoquinoline was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem