Jiang, Xingjun; He, Jianbo; Chen, Hongli; Yang, Weiqing; Zhang, yuanyuan; Ma, Menglin published the artcile< Copper-catalyzed hydrolysis of bromoisoquinolines: preparation of hydroxyisoquinolines>, HPLC of Formula: 3336-49-0, the main research area is hydroxyisoquinoline preparation; bromoisoquinoline copper catalyst hydrolysis.
A complex phenomenon was observed in the process of preparing hydroxyisoquinoline through copper-catalyzed hydrolysis of bromoisoquinoline. The copper (II) complexes of hydroxyisoquinoline (L2Cu.5H2O) were characterized by high resolution mass spectra, thermogravimetric anal., IR, 1H NMR (NMR), and 2D-NMR. The Cu (II) complexes were mononuclear and coordinated with oxygen and nitrogen atom of two hydroxyisoquinoline and five water mols. in which a strong hydrogen bond was present. Two optimized methods were studied to prevent the formation of copper (II) complexes. The isoquinoline with 4, 5, 6, 7, and 8 hydroxyl substitutions were successfully prepared by copper-catalyzed hydrolysis of corresponding bromoisoquinoline and then workup by sodium sulfide or adjusted pH by dry ice or carbon dioxide gas.
Indian Journal of Heterocyclic Chemistry published new progress about Hydrolysis. 3336-49-0 belongs to class isoquinoline, and the molecular formula is C9H7NO, HPLC of Formula: 3336-49-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem