《Synthesis of 3,4-dihydro-1(2H)-isoquinolinones》 was written by Showalter, H. D. Hollis; Sercel, Anthony D.; Stier, Michael A.; Turner, William R.. Safety of 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one And the article was included in Journal of Heterocyclic Chemistry on August 31 ,2001. The article conveys some information:
Approaches toward the preparative-scale synthesis of target 3,4-dihydro-1(2H)-isoquinolinones [I; R = 7-Me, 5-Me, 5-O(CH2)3NHMe] are presented. I (R = 7-Me, 5-Me) were prepared via a Schmidt rearrangement on easily obtained indanone precursors, but in low overall yield. A better method to make this class of compounds is exemplified by the large-scale synthesis of I (R = 5-Me) via a Curtius rearrangement sequence. Thus, high-temperature thermal cyclization of an in situ formed styryl isocyanate in the presence of tributylamine gave the corresponding 1(2H)-isoquinolinone, which underwent catalytic hydrogenation to provide the desired I (R = 5-Me) in 65% overall yield. Similar reduction of a com. available 5-hydroxy-1(2H)-isoquinolinone precursor, followed by an O-alkylation/amination sequence, gave target I [R = 5-O(CH2)3NHMe] in good overall yield. The route proceeding via the Curtius rearrangement is recommended for large scale synthesis of other 3,4-dihydro-1(2H)-isoquinolinones. Only when deactivating substituents or sensitive functionality within the benzenoid ring render the high temperature ring closure of the intermediate isocyanate inefficient might a Schmidt rearrangement protocol be the method of choice. In the experiment, the researchers used 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one(cas: 129075-56-5Safety of 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one)
5-Methyl-3,4-dihydroisoquinolin-1(2H)-one(cas: 129075-56-5) belongs to isoquinoline.Safety of 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem