COA of Formula: C10H11NOOn September 20, 2000 ,《Beckmann rearrangements of 1-indanone oxime derivatives using aluminum chloride and mechanistic considerations》 was published in Bulletin of the Korean Chemical Society. The article was written by Lee, Byoung Se; Chu, Soyoung; Lee, In Young; Lee, Bon-Su; Song, Choong Eui; Chi, Dae Yoon. The article contains the following contents:
Hydrocarbostyril, which is a key intermediate in a new synthetic route to 6-nitroquipazine, can be prepared from 1-indanone oxime by Beckmann rearrangement. The reaction was optimized to 91% yield by using a Lewis acid, AlCl3, instead of common acids such as polyphosphoric acid, and H2SO4 used in conventional Beckmann rearrangement (20% in the literature, 10% in the authors’ experiment). The optimized condition was established with 3 equiv AlCl3 in CH2Cl2 at -40° to room temperature for 40 min. These conditions were applied to other 1-indanone derivatives, such as 4-methyl-, 4-methoxy- and 4- and 6-nitro-1-indanones. The mechanism of this reaction was proposed on the basis of the effect of temperature and substituent on product ratio, with the aid of PM3 calculation for a model system. After reading the article, we found that the author used 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one(cas: 129075-56-5COA of Formula: C10H11NO)
5-Methyl-3,4-dihydroisoquinolin-1(2H)-one(cas: 129075-56-5) belongs to isoquinoline.COA of Formula: C10H11NO Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem