Khanapure, Subash P.; Han, Wei; Swartling, Dan J.; Biehl, Edward R. published the artcile< Synthesis of fluorine-substituted anthraquinones and aza-anthraquinones>, Name: 6,9-Difluorobenzo[g]isoquinoline-5,10-dione, the main research area is fluoro anthraquinone azaanthraquinone; anthraquinone fluoro; benzquinolinone fluoro; mitoxantrone fluoroanthraquinone intermediate; ametantrone fluoroanthraquinone intermediate; aza anthraquinone fluoro.
Using 1,4-dipolar-aryne cycloaddition methodol., a convenient, short synthesis of several fluoroanthraquinones I (R1 = H, methoxy, methoxymethoxy; n = integer) is presented which involves the reaction of haloarenes and 3-cyanophthalides in the presence of lithium diisopropylamide (LDA) in THF. The fluorine substituent(s) can be introduced by using fluorine-substituted haloarenes and/or 3-cyanophthalides. Similarly, fluorine-substituted pyridines, i.e. (fluoro)benz[g]isoquinoline-5,10-diones, II (R1 = H, methoxy, methoxymethoxy; n = integer) can be prepared by treating fluorine-substituted cyanophthalides and halopyridines in the presence of lithium diisopropylamide.
Journal of Fluorine Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 144511-13-7 belongs to class isoquinoline, and the molecular formula is C13H5F2NO2, Name: 6,9-Difluorobenzo[g]isoquinoline-5,10-dione.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem