On December 16, 2004, Yamada, Rintaro; Seto, Minoru published a patent.HPLC of Formula: 58142-46-4 The title of the patent was Preparation of diazaphenalene compounds as myosin-control light chains phosphorylation inhibitors. And the patent contained the following:
Title compounds I [R1 = H, chloro, OH; X1···X2 represents CH(R2)-CH(R3), etc.; R2, R3 = H, alkyl; A1, A11, A2, A21 = H, alkyl; Y = CH(A3), etc.; A3 = H, alkyl; Z = OH, etc.] were prepared For example, cyclization of compound II using potassium tert-butoxide followed by deprotection of tert-butoxycarbonyl group with HCl afforded compound III hydrochloride. In myosin regulatory light chains phosphorylation inhibition assays, the IC50 value of compound III·HCl was ≤10 μM. Compounds I are claimed to be useful for the treatment of glaucoma, bronchial asthma, etc. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).HPLC of Formula: 58142-46-4
The Article related to diazaphenalene preparation myosin regulatory light chain phosphorylation inhibitor, antiglaucoma diazaphenalene preparation myosin regulatory light chain phosphorylation inhibition, antiasthmatic diazaphenalene preparation myosin regulatory light chain phosphorylation inhibition and other aspects.HPLC of Formula: 58142-46-4
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem