On June 1, 2006, Yamada, Rintaro; Seto, Minoru published a patent.Application In Synthesis of 4-Bromo-5-nitroisoquinoline The title of the patent was Preparation of diazaphenalene derivatives as myosin-control light chains phosphorylation inhibitors. And the patent contained the following:
Title compounds I [R1, R5-R8 = H, halo, hydroxy, etc.; X1···X2 = -CH(R2)CH(R3)-, -CH(R2)CH(R3)CH(R4)-, -C(R2):C(R3)-, etc.; R2-R4 = H, alkyl; A1, A11, A2, A21 = H, alkyl; Y = -CH(A3)-, -CH(A3)C(A4)(A41)-, single bond, etc.; A3, A4, A41 = H, alkyl; Z = hydroxy, -NR(A6)(A61); A6 = H, alkyl; A61 = H, alkyl, alkyl substituted with aryl group, etc.; further details on A1-A4 and A6 are given.] and salts thereof were prepared For example, reductive amination of tert-Bu 3-oxo-1-piperidinecarboxylate with 5-amino-4-vinylisoquinoline, e.g., prepared from 5-amino-4-bromoisoquinoline, followed by reaction with potassium tert-butoxide and treatment with HCl afforded compound II hydrochloride. In myosin-control light chains phosphorylation inhibition assays, compound II hydrochloride exhibited the IC50 value of ≤10 μM. Compounds I are claimed useful for the treatment of glaucoma, bronchial asthma, etc. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Application In Synthesis of 4-Bromo-5-nitroisoquinoline
The Article related to diazaphenalene preparation myosin control light chain phosphorylation inhibitor, glaucoma bronchial asthma treatment diazaphenalene preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 4-Bromo-5-nitroisoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem