On July 14, 2005, Fernandes, Prabhavathi B.; Mailman, Richard Bernard; Nichols, David Earl; Postlethwait, Robert Neil published a patent.Computed Properties of 58142-46-4 The title of the patent was Preparation of dopamine D1 receptor agonists and co-administration with D2 receptor antagonists for treatment of neurological and psychiatric disorders. And the patent contained the following:
Methods for treating a patient having neurol., psychotic, and psychiatric disorders are described comprising the steps of administering to the patient an effective amount of a partial and/or full dopamine D1 receptor agonist, and administering to the patient an effective amount of a dopamine D2 receptor antagonist. Pharmaceutical compositions comprising a dopamine D1 receptor agonist and a dopamine D2 receptor antagonist are also described. The D1 dopamine receptor agonist and the D2 dopamine receptor antagonist can be administered to the patient in the same or in a different composition or compositions The agonist is a compound selected from the group consisting of hexahydrobenzophenanthridines, hexahydrothienophenanthridines, phenylbenzodiazepines, chromenoisoquinolines, naphthoisoquinolines, and their analogs, derivatives and pharmaceutically acceptable salts; the synthesis of such compounds is disclosed. The dopamine D2 receptor antagonist is specifically claimed to be an antipsychotic agent. The pharmaceutical composition further comprise one or more cholinergic agents, cholinergic agonists, acetylcholine mimetics, acetylcholine esterase inhibitors, or combinations thereof. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Computed Properties of 58142-46-4
The Article related to dopamine receptor ligand neurol psychiatric disorder treatment, phenanthridine phenylbenzodiazepine isoquinoline analog preparation neurol disorder treatment, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Computed Properties of 58142-46-4
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem