With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23687-26-5,6-Aminoisoquinoline,as a common compound, the synthetic route is as follows.
Compound 7A (10.9 g, 25 mmol) at room temperature6-aminoisoquinoline (4.32 g, 30 mmol)And EDCI (6.68g, 35mmol)Add pyridine (100ml), nitrogen protection,Then DMAP (4-dimethylaminopyridine) (4.2 g, 35 mmol) was added,Reaction overnight,The reaction was monitored by TLC (DCM:MA=20:1) until the disappearance of starting compound 7A, evaporated to dryness under reduced pressure, 3 mol of acetic acid aqueous solution was adjusted to pH=4-5, extracted with DCM (100 ml*4), and combined to obtain compound 8. (11.02 g), yield 78percent; LC-MS (M+1) 566, purity: 97.4percent.
As the paragraph descriping shows that 23687-26-5 is playing an increasingly important role.
Reference£º
Patent; Shanghai Taoqin Bio-pharmaceutical Technology Co., Ltd.; Li Yu; (18 pag.)CN107434780; (2017); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem