1198-30-7, 1-Isoquinolinecarbonitrile is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1198-30-7, EXAMPLE X Preparation of N-[(1,2,3,4-Tetrahydro-2-methyl-1-isoquinolyl)methyl]-N-benzylpropionamide oxalate (TR-3389) Title Compound I, in which R=CH3 R’=H; X=H; A=CH; pY=C2 H2 O4 and q=0 and n=1 was prepared as follows: 1-Cyanoisoquinoline (15.4 g; 0.1 mole) was stirred and heated at reflux for 2.5 hours in 900 ml. of a 1:1 formic acid water solution with 30 g of Raney nickel alloy. The reaction was filtered and the filtrate made basic with 20% NaOH. The resulting suspension was extracted with dichloromethane whereupon the organic layer was separated, dried over MgSO4 and evaporated in vacuo to leave 9.5 g of a green oil. The crude oil was chromatographed through a silica gel column with ethyl acetate; evaporation of the ethyl acetate in vacuo left 7.5 g (40% theory) of 1-formamidoisoquinoline as a yellow oil. This compound was converted to the methiodide salt and reduced catalytically as in Example I to give a 50% yield of 1-formamidomethyl-2-methyl-1,2,3,4-tetrahydroisoquinoline as a yellow oil, 4 g (0.02 mole) of which was refluxed for 60 minutes in 10 ml of concentrated HCl.
1198-30-7 1-Isoquinolinecarbonitrile 306057, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; Miles Laboratories, Inc.; US4232160; (1980); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem