With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.679433-91-1,5-Bromo-8-methoxyisoquinoline,as a common compound, the synthetic route is as follows.,679433-91-1
5-bromo-8-methoxyisoquinoline (56 mg, 0.235 mmol), N-(6-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)naphthalen-2-yl)thiophene-3-carboxamide (~100 mg), Fibercat palladium catalyst (Johnson-Matthey, 10 mg), and K2CO3 (2 M in water, 0.25 ml, 0.5 mmol) were combined in a microwave reaction vessel and 1,4-dioxane (2 ml) was added. The reaction tube was sealed and heated in the microwave (CEM microwave) at 150 Watts and 100 C for 10 minutes. The reaction was cooled to room temperature and diluted with water and dichloromethane. The organic extracts were combined, dried over sodium sulfate, filtered, concentrated, and purified two times using the ISCO purification system (40 g column, 0 -> 5% MeOH / CH2Cl2) and one time using Varian prep HPLC (1% -95% MeCN / water with 0.1% TFA over 70 minutes) to afford title compound (5 mg, 5%) contaminated with EPO
The synthetic route of 679433-91-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AMGEN INC.; WO2007/5668; (2007); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem