18881-17-9, (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,18881-17-9
To 30.2g [(3S) – 1, 2, 3, 4-tetrahydrosquinoline-3-yl] methanol (185mmol) in 750 ml of methylene chloride is added in solution 91.71g toluene sulfonyl chloride (481mmol), then dropwise 122.3mLN, N, N-triethylamine (740mmol). Then the temperature of the reaction mixture is stirred for 20 hours. Furthermore, the dichloromethane is used for dilution, for sequentially 1MHCl solution, saturated NaHCO3solution, then washed with saturated NaCl solution until neutral. Then the organic phase through MgSO4drying, filtering, concentrated to dry. Then the obtained solid is dissolved in a minimum volume of methylene chloride, then adding cyclohexane to form precipitate. Then filtering out the precipitated, with cyclonexane washing. After drying, the title of the crystalline form of the product is obtained.
18881-17-9 (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 776757, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; France Servier Pharmaceuticals; p, Casara; T, Le Diguaher; J-M, Henlin; J-B, Starck; A, Le Tiran; G, De Nanteuil; O, Geneste; J¡¤E¡¤P, Davidson; J¡¤B, Murray; I-J, Chen; C, Walmsley; C¡¤J, Graham; S, Ray; D, Maddox; S, Bedford; (116 pag.)CN105408321; (2016); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem