With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215453-53-5,7-Bromoisoquinolin-1-amine,as a common compound, the synthetic route is as follows.
Example 1 (Compound No. 2 of table 1) 10-Bromo-2-pyridin-4-yl-4H-pyrimido[2,1-a]isoquinolin-4-one oxalate (1:1) ; To a mixture of 0.1g (0.38 mmol) of 7-bromoisoquinolin-1-amine (synthesis described in WO9847876) and 0.134g (0.69 mmol) of ethyl 3-(4-pyridinyl)-3-oxopropionate were added 0.059g (0.77 mmol) of ammonium acetate. The reaction mixture was heated at 140C for 12 hours. Then 2ml of Dowtherm A were added and the resulting mixture was allowed to stir at 210C for 8 hours. After cooling, water was added and the resulting solution was acidified using isopropanol hydrochloride 6N. Dowtherm A was extracted using diethyl ether and the aqueous phase was basified by an aqueous solution of sodium hydroxide (30%) and extracted with dichloromethane. The extracts were dried over sodium sulphate and evaporated. The residue obtained was purified by chromatography on silica gel eluting with a mixture of dichloromethane/methanol in the proportions 99/1 to 95/5 to give 0.041g (30%) of the desired compound which was transformed into the oxalate salt in the usual manner to give the pure product as a solid. MP: 244-246C RMN 1H (DMSO-d6; 200 MHz) delta (ppm) : 9.25 (s, 1H), 8.80 (d, 2H), 8.70 (d, 1H), 8.30 (d, 2H), 8.10 (dd, 1H), 8.00 (dd, 1H), 7.65 (d, 1H), 7.40 (s, 1H)., 215453-53-5
The synthetic route of 215453-53-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; sanofi-aventis; Mitsubishi Tanabe Pharma Corporation; EP2138495; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem